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Table 2 IVF/ICSI outcomes of individuals with GDF9 bi-allelic variants

From: GDF9His209GlnfsTer6/S428T and GDF9Q321X/S428T bi-allelic variants caused female subfertility with defective follicle enlargement

 

P1-1

P1-2

P2

Gn starting dose (IU)

150

225

300

Days of Gn stimulation

25

13

24

Total Gn dosage (IU)

6300

2925

8025

E2 level on the day of hCG injection (pg/ml)

614

386

1822

 

L-OV

R-OV

L-OV

R-OV

L-OV

R-OV

Number of follicles at hCG injection

 da ≥18

0

0

0

0

0

1

 15 ≤ d <18

0

0

0

0

2

2

 10 ≤ d <15

1

3

2

1

3

0

 5 ≤ d <10

2

1

6

4

8

8

Retrieved oocytes

0

3

3

2

8

1

Fertilization method

/

ICSI

IVF

Fertilization rate (2PN)

/

2/5

8/9

High-quality embryo rate (D3)

/

2/2

3/8

  1. P1-1 the first therapy cycle of individual P1, P1-2 the second therapy cycle of individual P1, L-OV left ovary, R-OV right ovary, IVF in vitro fertilization, ICSI intracytoplasmic sperm injection
  2. ad= diameters