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Fig. 7 | Cell Communication and Signaling

Fig. 7

From: Exploring the role of Prx II in mitigating endoplasmic reticulum stress and mitochondrial dysfunction in neurodegeneration

Fig. 7

Prx II is a promising target for the treatment of neurodegenerative diseases induced by oxidative stress via mitochondrial membrane potential decrease. By regulating EMCSs, Prx II can prevent the accumulation of Ca2+ in the mitochondrial matrix, which can stimulate the formation and opening of the MPTP, leading to the release of Ca2+ and apoptotic factors into the cytoplasm, and the induction of cell death

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Cell Communication and Signaling

ISSN: 1478-811X