Fig. 9
From: Structural determinants for activation of the Tau kinase CDK5 by the serotonin receptor 5-HT7R
Graphical summary. The 5-HT7R WT stimulates the Gs signaling pathway resulting in increased cellular cAMP concentrations. In addition, 5-HT7R WT activates the Tau kinase CDK5 in G protein-independent manner leading to pathological Tau hyperphosphorylation and subsequent Tau aggregation (middle panel). 5-HT7R mutants that impair the Gs-mediated signaling do not affect the CDK5 signaling (left panel), while 5-HT7R mutants that inhibit the 5-HT7R/CDK5 interaction block the CDK5 signaling without affecting physiological Gs signaling (right panel)