Fig. 8
From: Structural determinants for activation of the Tau kinase CDK5 by the serotonin receptor 5-HT7R
Mutation binding energy calculations in the 5-HT7R/CDK5 models refined by molecular dynamics. A PPI binding free energy mutation analysis of the m5-HT7R/CDK5 model. Mutation energy values for the top 5 disrupting residues are labeled. B PPI binding free energy mutation analysis of the h5-HT7R/CDK5 model. Mutation energy values for the top 5 disrupting residues are labeled. C 3D view of 5-HT7R residues interacting with CDK5 ɑC-helix hydrophobic surface D 3D view of the 5-HT7R residues interacting with CDK5 charged anionic N-lobe surfaces. In structural images, CDK5 residues are shown in yellow, m5-HT7R – red, h5-HT7R – sky blue