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Fig. 9 | Cell Communication and Signaling

Fig. 9

From: RUNX1-BMP2 promotes vasculogenic mimicry in laryngeal squamous cell carcinoma via activation of the PI3K-AKT signaling pathway

Fig. 9

BMP2 promotes LSCC VM and metastasis by activating the PI3K-AKT pathway. A KEGG enrichment analysis of differentially expressed genes. B Western blot analysis of p-PTEN, p-PDK, p-Akt, and Akt in LSCC. C Overexpression efficiency of BMP2 was verified using qRT-PCR. D, F–H Transwell migration, Transwell invasion, and scratch wound-healing assays were performed in three groups (DMSO, BMP2 + DMSO, and BMP2 + MK2206), respectively. E, I, J Tubule formation and spheroid invasion assays were conducted in the same three groups. K, L Western blot analysis of BMP2, p-PTEN, p-PDK, p-Akt, and Akt in the three groups in TU212 and TU686 cells. ***P < 0.001, ****P < 0.0001, Student’s t-test and two-way ANOVA

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Cell Communication and Signaling

ISSN: 1478-811X