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Fig. 8 | Cell Communication and Signaling

Fig. 8

From: RUNX1-BMP2 promotes vasculogenic mimicry in laryngeal squamous cell carcinoma via activation of the PI3K-AKT signaling pathway

Fig. 8

In vivo knockdown of BMP2 inhibits LSCC VM and metastasis. Representative Matrigel plugs are shown, n = 3. B ImageJ software was used to count and analyze tubules. C Images of solid tumors from nude mice. D Curves of xenograft tumor growth in nude BALB/c mice (n = 4). E Western blot analysis of the expression of BMP2 in xenograft tumors. F IHC staining for BMP2 and CD34/PAS, CD34 − PAS + vasculogenic mimicry (VM) tubes. G IHC analysis of EMT markers in TU212 xenografts. H–J) Lung metastasis model. K Statistical analysis of nodules. L, M A zebrafish model was used to analyze the dissemination and metastasis of TU212 cells. **P < 0.01, ***P < 0.001, Student’s t-test

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Cell Communication and Signaling

ISSN: 1478-811X