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Fig. 7 | Cell Communication and Signaling

Fig. 7

From: RUNX1-BMP2 promotes vasculogenic mimicry in laryngeal squamous cell carcinoma via activation of the PI3K-AKT signaling pathway

Fig. 7

In vitro knockdown of BMP2 inhibits LSCC VM and metastasis. A-C Validation of BMP2 knockdown by qRT-PCR and western blotting. D Tubule formation assay of TU212 and TU686 cells. E 3D cell spheroid invasion assay of TU212 and TU686 cells. F–G Column graph in index of tubule formation and spheroid invasion ratio. H Immunofluorescence (IF) revealed that changes in the expression of BMP2 altered the expression of EMT markers. I Western blot analysis of EMT markers. Scratch wound-healing (J) and Transwell migration and invasion (K) assays performed in TU212 and TU686 cells. ***P < 0.001, ****P < 0.0001, Student’s t-test and two-way ANOVA

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Cell Communication and Signaling

ISSN: 1478-811X