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Fig. 11 | Cell Communication and Signaling

Fig. 11

From: RUNX1-BMP2 promotes vasculogenic mimicry in laryngeal squamous cell carcinoma via activation of the PI3K-AKT signaling pathway

Fig. 11

RUNX1 regulates BMP2 to promote vasculogenic mimicry in LSCC. A-B IHC results of RUNX1, BMP2 and CD34/PAS in LSCC tissue. C, E, F Tubule formation and spheroid invasion assays. D, G, H Transwell migration assay and transwell invasion assay. I Three groups (NC + NC, NC + shRUNX1, shRUNX1 + BMP2) of solid tumors were observed. J Curves of xenograft tumor growth in nude BALB/c mice (n = 4). K IHC staining for RUNX1, BMP2 and CD34/PAS in tumor tissues of nude mice. L Western blot analysis of EMT-related proteins and the AKT signaling pathway. M, N Kaplan–Meier curve for the 5-year overall survival rate of RUNX1 and BMP2. **P < 0.01, ***P < 0.001, ****P < 0.0001, one-way ANOVA and two-way ANOVA

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Cell Communication and Signaling

ISSN: 1478-811X