Fig. 1
From: MiR-574-5p activates human TLR8 to promote autoimmune signaling and lupus
miR-574-5p is significantly up-regulated in the serum samples from human SLE patients and the serum and other tissues of lupus-prone B6.Faslpr mice. miR-574-5p levels were determined by qPCR as described in the Extended Materials and Methods in the Supplementary Information. NS, not significant; * P < 0.05, ** P < 0.01, *** P < 0.001. (a) Serum levels of miR-574-5p in SLE patients and healthy normal controls and as determined by qPCR. The t-test was performed with Mann Whitney post-test, with normal controls (n = 18) and SLE patients (n = 47). (b) Correlation between the serum miR-574-5p levels and the clinical SLE disease activity index (SLEDAI) scores in 47 SLE patients. (c) Serum levels of miR-574-5p in female B6.WT or B6.Faslpr mice at ages of 60-d, 90-d and 180-d as determined by qPCR (n = 3–6). (d) Kidney levels of miR-574-5p in female B6.WT or B6.Faslpr mice at ages of 60-d, 90-d and 180-d as determined by qPCR (n = 3–6). (e) miR-574-5p levels in the brain, heart, liver, lung, lymph node and spleen tissues of female B6.WT or B6.Faslpr mice at the age of 60-d and 180-d (n = 3)