Table 1 Roles and mechanisms of RNA methylation in HCC
From: Clinical significance of RNA methylation in hepatocellular carcinoma
Type | Regulator of RNA methylation | Expression | Functions in HCC | Related targets | Underlying mechanisms | Year | Reference |
|---|---|---|---|---|---|---|---|
Writer | METTL3 | Upregulation | Promotes cell proliferation, migration, and lung metastasis | SOCS2 | / | 2018 | [89] |
Writer | METTL3 | Upregulation | Promotes cell proliferation and inhibits cell apoptosis | EGFR | / | 2023 | [79] |
Writer | METTL3 | Upregulation | Promotes cell proliferation, migration, and invasion | miR6079 | miR24-2, H3K9me3, and Pim1 | 2020 | [81] |
Writer | METTL3 | Upregulation | Promotes cell viability, migration, and invasion | miR-589-5p | / | 2022 | [82] |
Writer | METTL3 | Upregulation | Promotes expansion, self-renewal, tumorigenicity, metastasis, and lenvatinib resistance of liver CSCs | FZD10 | WNT/β-catenin and Hippo signaling pathways | 2023 | [69] |
Writer | METTL3 | Downregulation | Inhibits cell autophagy and sorafenib resistance | FOXO3 | / | 2020 | [75] |
Writer | KIAA1429 | Upregulation | Promotes cell proliferation and motility | circDLC1 | MMP1 | 2021 | [90] |
Writer | KIAA1429 | Upregulation | Promotes cell proliferation and metastasis | GATA3 | / | 2019 | [83] |
Writer | WTAP | Upregulation | Promotes cell proliferation, cell cycle, and migration | ETS1 | / | 2019 | [78] |
Writer | ZCCHC4 | Upregulation | Promotes cell proliferation | 28SrRNA | / | 2019 | [84] |
Eraser | ALKBH5 | Upregulation | Promotes cell proliferation, migration, and invasion | circCPSF6 | PCBP2 and YAP1 | 2022 | [70] |
Eraser | ALKBH5 | Upregulation | Inhibits cell apoptosis and radiosensitivity, promotes cell proliferation | TIRAP | / | 2023 | [71] |
Eraser | ALKBH5 | Upregulation | Inhibits cell proliferation, migration, and invasion | LINC02551 | DDX24 | 2022 | [72] |
Eraser | FTO | Downregulation | Inhibits cell proliferation and metastasis | CircGPR137B | MiR-4739 | 2022 | [85] |
Reader | YTHDF2 | Upregulation | Promotes liver CSC, and lung metastasis | OCT4 | / | 2020 | [88] |
Reader | IGF2BP1 | Upregulation | Promotes expansion and lenvatinib resistance of liver CSCs | MGAT5 | / | 2021 | [91] |
Writer | NSUN2 | Upregulation | Promotes cell cycle, and sorafenib resistance | / | / | 2023 | [80] |
Writer | NOP2 | Upregulation | Promotes cell cycle, aerobic glycolysis, and proliferation | c-Myc | MAZ | 2023 | [76] |
Writer | NSUN2 | Upregulation | Promotes cell proliferation, migration, and invasion | H19lncRNA | G3BP1 | 2020 | [96] |
Writer | METTL1 | Upregulation | Promotes cell radiotherapy resistance | tRNA | / | 2023 | [97] |
Writer | METTL1 | Upregulation | Promotes cell proliferation, migration, and invasion | SLUG/SNAIL | / | 2023 | [98] |
Writer | METTL1 | Upregulation | Promotes cell proliferation, migration, invasion, and lenvatinib resistance | EGFR | / | 2023 | [77] |
Writer | METTL1 | Upregulation | Promotes cell proliferation, migration, and invasion | / | / | 2021 | [108] |
Writer | TRMT6/TRMT61A complex | Upregulation | Promotes cell cholesterol metabolism | / | / | 2021 | [73] |