Gene | Control | SC | Colchicine | SC + Colchicine | p-value |
---|---|---|---|---|---|
P21 | 1.00 ± 0.11 | 2.67 ± 0.20 | 0.97 ± 0.03 | 1.46 ± 0.08 | 0.0001 |
TNF-α | 1.00 ± 0.13 | 1.68 ± 0.08 | 1.56 ± 0.12 | 1.26 ± 012 | 0.0004 |
IL-1β | 1.00 ± 0.04 | 1.60 ± 0.31 | 1.18 ± 0.06 | 1.12 ± 0.25 | 0.0305 |
IL-6 | 1.00 ± 0.02 | 4.76 ± 1.12 | 0.98 ± 0.16 | 2.20 ± 0.27 | 0.0001 |
IL-8 | 1.00 ± 0.02 | 1.28 ± 0.20 | 1.15 ± 0.07 | 2.36 ± 0.09 | 0.0001 |
MCP-1 | 1.00 ± 0.04 | 1.38 ± 0.21 | 0.84 ± 0.11 | 0.06 ± 0.02 | 0.0001 |
ICAM-1 | 1.00 ± 0.05 | 8.16 ± 0.64 | 2.42 ± 0.22 | 4.38 ± 0.85 | 0.0001 |
E-Selectin | 1.00 ± 0.01 | 1.56 ± 0.20 | 0.79 ± 0.02 | 0.86 ± 0.09 | 0.0001 |
VCAM-1 | 1.02 ± 0.22 | 1.25 ± 0.16 | 1.12 ± 0.12 | 1.08 ± 0.28 | 0.5901 |
MMP-1 | 1.00 ± 0.09 | 30.74 ± 3.37 | 2.22 ± 0.14 | 36.02 ± 6.11 | 0.0001 |
MMP-2 | 1.01 ± 0.13 | 1.79 ± 0.17 | 0.90 ± 0.12 | 0.98 ± 0.10 | 0.0001 |
MMP-8 | 1.02 ± 0.25 | 2.32 ± 0.11 | 1.19 ± 0.04 | 2.35 ± 0.14 | 0.0001 |
MMP-10 | 1.01 ± 0.16 | 4.65 ± 0.61 | 5.66 ± 0.40 | 9.35 ± 0.88 | 0.0001 |
MMP-11 | 1.00 ± 0.02 | 1.95 ± 0.14 | 0.82 ± 0.07 | 0.81 ± 0.12 | 0.0001 |
TIMP-1 | 1.00 ± 0.07 | 1.14 ± 0.09 | 0.68 ± 0.11 | 0.33 ± 0.21 | 0.0003 |
TIMP-2 | 1.00 ± 0.08 | 2.39 ± 0.17 | 1.32 ± 0.10 | 2.10 ± 0.09 | 0.0001 |