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Table 1 Relative protein expression. The data were analyzed using one-way ANOVA followed by tukey’s test. SC = smoke condensate

From: Tobacco smoke condensate-induced senescence in endothelial cells was ameliorated by colchicine treatment via suppression of NF-κB and MAPKs P38 and ERK pathways activation

Protein

Control

SC

Colchicine

SC + Colchicine

p-value

KU70

1.00 ± 0.05

1.16 ± 0.00

1.01 ± 0.02

1.00 ± 0.02

0.0003

KU80

1.00 ± 0.09

1.19 ± 0.09

1.05 ± 0.03

1.04 ± 0.01

0.0382

Lamin B1

1.00 ± 0.14

0.76 ± 0.00

1.06 ± 0.05

1.09 ± 0.09

0.0046

P53

1.00 ± 0.21

2.03 ± 0.13

1.06 ± 0.28

0.75 ± 0.39

0.0019

P21

1.00 ± 0.10

1.86 ± 0.35

1.45 ± 0.09

0.70 ± 0.22

0.0009

MMP-2

1.00 ± 0.05

1.60 ± 0.02

1.37 ± 0.15

1.20 ± 0.11

0.0004

P65

1.00 ± 0.08

1.00 ± 0.05

0.96 ± 0.03

0.93 ± 0.00

0.2722

p-P65

1.00 ± 0.09

1.51 ± 0.09

0.91 ± 0.03

1.11 ± 0.01

0.0001

p-65/P65

1.00 ± 0.05

1.51 ± 0.05

0.96 ± 0.06

1.20 ± 0.01

0.0001

p-P38

1.00 ± 0.14

5.76 ± 0.29

0.94 ± 0.02

1.03 ± 0.06

0.0001

p-ERK

1.00 ± 0.04

1.90 ± 0.24

1.08 ± 0.10

0.72 ± 0.08

0.0001

p-JNK

100 ± 0.18

1.08 ± 0.14

0.95 ± 0.12

1.10 ± 0.05

0.5054

p-mTOR

1.00 ± 0.18

1.21 ± 0.11

1.18 ± 0.11

1.06 ± 0.14

0.2772

p-S6

1.00 ± 0.03

1.69 ± 0.03

1.52 ± 0.03

1.22 ± 0.09

0.0001

p-4EBP1

1.00 ± 0.10

0.94 ± 0.24

1.40 ± 0.04

1.52 ± 0.19

0.0057