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Fig. 3 | Cell Communication and Signaling

Fig. 3

From: Tobacco smoke condensate-induced senescence in endothelial cells was ameliorated by colchicine treatment via suppression of NF-κB and MAPKs P38 and ERK pathways activation

Fig. 3

Colchicine suppressed the transcription of SASP factors. The relative mRNA expression of (A) TNF-alpha, (B) IL-1b, (C) IL-6, (D) IL-8, (E) MCP-1, (F) ICAM-1 (G) E-Selectin, (H) VCAM-1, (I) MMP1, (J) MMP2, (K) MMP8, (L) MMP10, (M) MMP11, (N) TIMP1, (O) TIMP2. (P) WB showing protein expression of MMP2. (Q) Quantified Relative protein expression of MMP2. The experiments were performed with biological triplicates. β-actin was used as a control. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001

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Cell Communication and Signaling

ISSN: 1478-811X