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Fig. 6 | Cell Communication and Signaling

Fig. 6

From: Repetitive transcranial magnetic stimulation ameliorates cognitive deficits in mice with radiation-induced brain injury by attenuating microglial pyroptosis and promoting neurogenesis via BDNF pathway

Fig. 6

Inhibiting BDNF pathway reversed the anti-pyroptosis effect of rTMS. (A) Representative immunofluorescence double staining images of Iba-1 and GSDMD, arrows indicated co-localization of GSDMD with Iba-1. Scale bar = 100 μm. (B) The number of GSDMD/Iba-1 positive cells in DG. (C) Quantitative analysis of integrated intensity of GSDMD. (D) Representative bands of western blotting. (E-I) Quantitative analysis of protein expression level by one-way ANOVA followed by Tukey’s multiple comparison test. Data are presented as mean ± S.E.M, n = 3 for each group. *P < 0.05, **P < 0.01, ***P < 0.001 vs. Sham group; #P < 0.05, ##P < 0.01, ###P < 0.001 vs. Radiation group; &P < 0.05, &&P < 0.01, &&&P < 0.001 vs. rTMS group; ns. no significance

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Cell Communication and Signaling

ISSN: 1478-811X