Fig. 4

Inhibiting BDNF pathway reversed the improvement of cognitive function and emotionality induced by rTMS in RIBI mice. (A) Schematic diagram of the experimental design, including animal grouping, drug administration, intervention protocol, behavioral tests and other experiments. (B) The escape latency during navigation test phase. (C) The time spent in the target quadrant during probe test phase. (D) The number of platform crossings during probe trial. (E) The locomotion total distance in open field. (F) The total time spent in central area of open field. (G) The frequency of central entries in open field. (H) The time spent in open arms of elevated plus maze. (I) The frequency of open arms entries. (J) Representative MWM training trace of mice in each group. (K) Representative movement trace of mice in the open field, the four squares in the middle represent central area. (L) Representative movement trace of mice in the elevated plus maze, open and closed arms are indicated in the diagrams. Data are presented as mean ± S.E.M, n = 11 or 12 for each group. ^*P < 0.05, ^**P < 0.01 vs. Sham group; ^#P < 0.05, ^##P < 0.01 vs. Radiation group; ^&P < 0.05, ^&&P < 0.01 vs. rTMS group; ns. no significance