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Fig. 2 | Cell Communication and Signaling

Fig. 2

From: Repetitive transcranial magnetic stimulation ameliorates cognitive deficits in mice with radiation-induced brain injury by attenuating microglial pyroptosis and promoting neurogenesis via BDNF pathway

Fig. 2

rTMS attenuated microglia pyroptosis induced by NLRP3 inflammasome. (A) Immunohistochemical staining of Iba-1 for indication of microglia in hippocampus. Scale bar = 100 μm, the enlarged image indicated the morphology of microglia. (B) The number of Iba-1+ in DG region. Data are presented as mean ± S.E.M. (C) Immunofluorescence staining of GSDMD and Iba-1, the arrows indicate co-localization of GSDMD with Iba-1. Scale bar = 50 μm. (D) The quantitative analysis of number of GSDMD+/Iba-1+ in DG region. (E-J) Western blotting representative bands and quantitative analysis. Protein expression level was normalized to β-actin. The data are presented as mean ± S.E.M, n = 3 for each group. *P < 0.05; **P < 0.01; ***P < 0.001 vs. Sham group, #P < 0.05; ###P < 0.001 vs. Radiation group

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Cell Communication and Signaling

ISSN: 1478-811X