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Fig. 8 | Cell Communication and Signaling

Fig. 8

From: Single cell analysis reveals the roles and regulatory mechanisms of type-I interferons in Parkinson’s disease

Fig. 8

In silico gene perturbation and in vivo validation for NFATc2. A Venn diagram shows the overlap of transcription factors regulating the NF-κB, IFN-I response, and inflammatory response pathway. B The in silico gene perturbation results suggest key genes involved in the transition from high IFN-I microglial cells to low IFN-I microglial cells. C Iba1 show the increasing trend of microgliosis in MPTP-treated mice. D-G Western blot results for NFATc2 (E), IRF9 (F), and p-STAT1/ STAT1(G)

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Cell Communication and Signaling

ISSN: 1478-811X