Fig. 6

Identification of combinatorial regulon modules and Cell-type-specific regulon activity analysis. A Combinatorial regulation modules are identified based on regulatory connection specificity index matrices, along with representative transcription factors, corresponding binding motifs, and associated cell types. B Rank for regulons in Microglia based on regulon specificity score (RSS). C The t-SNE map highlights microglia (red dots). D A t-SNE map with binarized regulon activity scores (RAS) for top regulon NFATc2 (dark green dots). E Seek co-expression results for top regulon NFATc2 target genes in different GEO datasets. Each dataset is represented by an x axis, and its co-expression significance is represented by each y axis. Microglia related datasets with significant correlation (p-value < 0.01) are highlighted by yellow dots. F, G Same as E, D but for RUNX2. H, I Same as D, E but for IRF5