Fig. 1

Profiling of the gut microbiota and short-chain fatty acids (SCFAs) in patients with AChR MG. (A) LEfSe clustering tree. Yellow color represents healthy controls (HCs, n = 11), and black color represents patients with AChR MG (n = 22). Nodes of different colors represent microbial groups that play an important role in the group represented by the color. (B) The relative abundance of Clostridia (Mann-Whitney U = 58, p = 0.0153), Gammaproteobacteria (Mann-Whitney U = 61, p = 0.0213), Bacilli (Mann-Whitney U = 25, p < 0.0001), Actinobacteria (Mann-Whitney U = 69, p = 0.0481), Clostridium cluster _XlVa (Mann-Whitney U = 37, p = 0.0008) and Roseburia (Mann-Whitney U = 54, p = 0.0094) in HCs compared to patients with AChR MG. (C) The concentrations of acetic acid, propionic acid, butyric acid (Mann-Whitney U = 5.5, p = 0.0008), valeric acid, and caproic acid in the sera of HCs and patients with AChR MG. Each dot represents an individual sample. * p < 0.05, ** p < 0.01, *** p < 0.001, ns = not significant