Fig. 1
From: Role of STING in the treatment of non-small cell lung cancer
In the LLC model, STING can reduce CD8+ T cell infiltration and tumor cell killing, while increasing MDSC infiltration and IL-10 production in the TME. Furthermore, STING can induce local IDO activity to promote LLC growth in low antigenicity TME. SAMHD1 overexpression can negatively regulate STING in lung cancer and inhibit tumor proliferation. In addition, STING-mediated IFI16 degradation can negatively regulate IFI16-mediated p53-dependent apoptosis and downstream IFN-I production in NSCLC, which can promote tumor proliferation