Endogenous estrogen metabolites as oxidative stress mediators and endometrial cancer biomarkers

Table 1 Potential biomarkers for endometrial cancer in biofluids

Estrogen Metabolite as Potential Biomarker	Biofluids	Level in the Endometrial Cancer Cases Compared with the Controls	References
Estrone	Serum	↑ or ↔	13,16,17,21,36
Estradiol	Serum	↑	13,16,17,21,36
Estradiol	Urine	↑	14
2-Hydroxyestrone	Serum	↑	36, 37
2-Hydroxyestrone	Urine	↔	14
2-Hydroxyestradiol	Serum	↑ or ↔	36, 37
2-Hydroxyestradiol	Urine	↔	14
2-Methoxyestrone	Serum	↔	36, 37
2-Methoxyestrone	Urine	↓	14
2-Methoxyestradiol	Serum	↔	36, 37
2-Methoxyestradiol	Urine	↓	14
4-Hydroxyestrone	Serum	↑	36, 37
4-Hydroxyestrone	Urine	↔	14
4-Hydroxyestradiol	Serum	↑	36, 37
4-Hydroxyestradiol	Urine	↑	14
4-Methoxyestrone	Serum	↔	36, 37
4-Methoxyestradiol	Serum	↔	36, 37
16alpha-Hydroxyestrone	Serum	↑	36, 38
16alpha-Hydroxyestrone	Urine	↔	14
Estriol	Serum	↑ or ↔	37

ISSN: 1478-811X