Fig. 2
From: CDK7 in breast cancer: mechanisms of action and therapeutic potential
Role of CDK7 in regulating the cell cycle (a), transcription (b) and DNA repair (c). (a) The CAK complex phosphorylates the T-loop of key cell cycle CDKs, including CDK1, 2, 4, and 6. (b) As a component of TFIIH, CDK7 catalyzes the phosphorylation of Ser5 and Ser7 within the RNA Pol II C-terminal domain. (c) In DNA repair, the dislodgement of MAT1 from its binding sites on the TFIIH core complex results in the release of the 3-subunit CAK module. The CAK complex interact and the activate p53 through phosphorylating at Ser-33. In a reciprocal manner, p53 downregulates CAK kinase activity.