Fig. 1
From: CDK7 in breast cancer: mechanisms of action and therapeutic potential
Structure of CAK and TFIIH. (a) CDK7, an enzyme comprising 346 amino acids. The N-terminal cyclin H-binding lobe (residues 13–96) primarily consists of β sheets and one α helix, while the C-terminal MAT1 binding lobe (residues 97–311) is predominantly composed of α helices. The N-terminal residues 1–12 and C-terminal residues 312–346 feature a putative nuclear localization sequence. (b) The structural of the MAT1 includes the RING domain and helical regions in the MAT1 N-terminus, and the CAK anchor in the MAT1 C-terminus.