Fig. 2
From: Advances in lymphatic metastasis of non-small cell lung cancer
Main signaling pathways and major therapeutic targets contributing to lymphangiogenesis and lymphatic metastasis in NSCLC. In NSCLC, tumor cells induce the secretion of various factors that promote LECs-mediated lymphangiogenesis. Meanwhile this process contributes to the acquisition of the aggressive phenotypes, such as proliferation, migration, invasion, EMT, drug-resistance, and apoptosis in cancer cells