Fig. 8

Glycosylation site occupancy. A Volcano plots of expression patterns of identified proteins. Red dots: up-regulated proteins. Green dots: down-regulated proteins. The value q (-log10) is plotted against the log2 (FC: disease group vs. normal group). B Lists of concertedly up-regulated proteins in patients with liver disease (CHB, LC, or HBV-HCC) compared to HC. C GO enrichment analysis of the concertedly up-regulated proteins in HBV-HCC. D Levels of peptides from IgA1 and IgG2, including IgA1[127–153], IgA1[332–353] and IgG2[168–180] in HC, CHB, LC and HBV-HCC. E Average glycosylation site occupancy in HC, CHB, LC and HBV-HCC. Glycosylation site occupancy was calculated by dividing the abundance of a given type of glycoform by the total corresponding peptide (glycopeptide and non-glycopeptide) abundance. F Glycosylation site occupancy of IgA1[127–153], IgA1[332–353] and IgG2[168–180]. G Fucosylation site occupancy of IgA1[127–153], IgA1[332–353] and IgG2[168–180]