Fig. 4

Quantitative glycoprotemic analysis of HC, CHB, LC and HBV-HCC serum samples. A Venn diagram of intact glycopeptides identified from HC, CHB, LC and HBV-HCC samples. B Distribution of glycan subtypes from intact glycopeptides identified from HC, CHB, LC and HBV-HCC samples. C Volcano plots of expression patterns of identified glycopeptides. Red dots: up-regulated glycopeptides. Green dots: down-regulated glycopeptides. The value q (-log10) is plotted against the log10 (FC: disease group vs. normal group). D Classification of differentially expressed intact glycopeptides based on their attached glycan structures. The numbers indicate the unique glycopeptides modified by the corresponding glycans