Fig. 1

Differentially expressed glycan-related genes in HBV-related HCC of GSE135631 and GSE94660. A Workflow of the present study. B Volcano plot of expression patterns of identified genes in GSE135631 and GSE94660. Red dots: up-regulated genes. Green dots: down-regulated genes. Highlighted dots: DEGGs. The q value (log10) is plotted against the log10 (FC: HBV-HCC tissues vs. adjacent tissues) using the cut-offs of fold change > 1.5 or < 0.67 and p value < 0.05. C PLS-DA plot of DEGGs in GSE135631 and GSE94660. D Heatmap showing the expression pattern of DEGGs in HBV-HCC and adjacent tissues of GSE135631 and GSE94660. E Functional enrichment analysis of DEGGs. F The PPI network of DEGGs performed by the STRING database and cytoscape tools. The red colour intensity was proportional to the degree of connectivity. G The mRNA expression of 13 FUTs, PIGV, PIGT, PIGM and B4GALT3 genes in 3 pairs of HBV-HCC and adjacent tissues determined by RT-qPCR