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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: Interleukin-4 from curcumin-activated OECs emerges as a central modulator for increasing M2 polarization of microglia/macrophage in OEC anti-inflammatory activity for functional repair of spinal cord injury

Fig. 4

Immunohistochemical analysis of involvement of IL-4 from aOECs in microglial polarization from M1 to M2 switch in LPS-induced microglial cells. a Immunofluorescence revealed expression of M1 markers (iNOS and CD86) and M2 markers (Arg-1 and CD206), respectively, in Iba1-positive cells treated under the indicated conditions for 36 h. b Quantification of the cytosol intensity for the indicated M1 and M2 markers. c Western blot analysis of M1 and M2 marker expression in microglial cells treated with the indicated conditions. All data are shown as the mean ± SEM of 3 independent experiments and normalized to normal controls. *p < 0.05, **p < 0.01 vs corresponding controls (Con). Scale bars = 100 μm

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Cell Communication and Signaling

ISSN: 1478-811X