Fig. 7

Potential models for GOLGA7 regulation on NRAS transport based on its different exit sites from the Golgi. (Full arrows) classical model: in the normal condition, NRAS undergoes conventional trafficking from the cis-Golgi to the trans-Golgi and then reaches the plasma membrane. In this case, GOLGA7 may regulate the anterograde trafficking of NRAS from the cis-Golgi to the trans-Golgi. In the condition of GOLGA7 depletion, the intra-Golgi transport of NRAS is disturbed and results in its accumulation at the cis-Golgi. (Dashed arrows) alternative model: in the normal condition, NRAS vesicles can bud directly from the cis-Golgi. In this case, GOLGA7 may play a role in the budding process of NRAS. In the condition of GOLGA7 depletion, the budding process of NRAS is disturbed and results in its accumulation at the cis-Golgi. Image created with BioRender.com