Fig. 1
From: Pyroptosis: a double-edged sword in lung cancer and other respiratory diseases
Activation mechanism of pyroptosis in the respiratory system in the canonical pathway and the non-canonical pathway. In canonical pathway, the NLRP3 inflammasome is taken as a representative example. The NLRP3 inflammasome consists of NLRP3, an important member of NLRs (NOD-like receptors), ASC, and pro-caspase-1. In addition to NLRs and pyrin, absent in melanoma 2 (AIM2) can also form inflammasomes to activate pyroptosis