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Fig. 7 | Cell Communication and Signaling

Fig. 7

From: CBX4-dependent regulation of HDAC3 nuclear translocation reduces Bmp2-induced osteoblastic differentiation and calcification in adamantinomatous craniopharyngioma

Fig. 7

Schematic diagram of the proposed mechanism supported by our results. Bmp2 increases miR-181b levels to directly target and inhibit CBX4 expression, leading to a reduction in CBX4-dependent regulation of HDAC4 nuclear translocation. Subsequently, this process promotes Runx2 activation (osteoblastic differentiation) and calcium deposition in ACP

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Cell Communication and Signaling

ISSN: 1478-811X