Fig. 3
From: Tumor microenvironment complexity and therapeutic implications at a glance
Design and working principle of aptamer-dendrimer (G4.5) nanomaterial for dual targeting of CTCs to reduce cancer metastatic burden. A, schematics of ring aptamers cCAP1 for targeting EpCAM and cCAP2 for targeting Her2 on CTCs. B, C, construction of aptamer ring conjugate (cCAP1-G4.5-cCAP2) for simultaneous binding and capturing of two CTC markers. D, Ex vivo analysis of CTCs in the blood of breast cancer patients captured by cCAP1-G4.5-cCAP2. Adapted with permission from [154]. Copyright (2017), American Chemical Society