Fig. 6
From: Viral manipulation of the cellular sumoylation machinery
Targeting the SENPs. Poxviruses, African Swine Fever virus (ASFV) and ADV encode viral SENP mimics. Poxvirus I7 protease and the ADV protease are structurally similar to the SENPs. While I7 de-sumoylating activity has not yet been determined, the ADV protease lacks de-sumoylating activity. The ASFV cysteine proteins pS273R specifically cleaves following viral di-glycine motifs, but its ability to de-sumoylate cellular proteins remains unknown. EBV LMP1 inhibits cellular SENP activity, possibly by sumoylating the SENPs, which aids the accumulation of modified proteins during latency. Inhibition of SENP activity also functions to inhibit HIV replication