Fig. 1
From: Kaiso differentially regulates components of the Notch signaling pathway in intestinal cells
Kaiso phenocopies loss of canonical Notch signaling independently of intestinal inflammation. a Hematoxylin & eosin (H&E) staining of 3-month (mo.) old Kaiso Tg intestines do not show widespread intestinal tissue damage due to chronic inflammation. b Myeloperoxidase (MPO) activity of 3-mo. old Kaiso Tg is unchanged relative to age-matched NonTg mice. c-e 3-mo. old Kaiso Tg mice exhibit an increase goblet (PAS - periodic acid Schiff), Paneth (Lysozyme) and enteroendocrine (EEC; ChrA - chromogranin A, yellow arrowheads) cell numbers relative to age-matched NonTg mice. Statistical significance determined using student’s t-test. Error bars are SEM, ***p < 0.0005. Scale bar, 50 μm