Fig. 10
From: HECTD1 controls the protein level of IQGAP1 to regulate the dynamics of adhesive structures
The role of HECTD1 in FAs formation. Upon binding of integrins to ECMs (e.g., Fibronectin), FAK/src signal pathway is activated and the recruitment of paxillin to the binding sites results in phosphorylation of paxillin at Y118 and the initiation of Focal complexs formation (a). Subsequently further recruitment of IQGAP1 passes the activation signals to small GTPases, such as Rac1 and RhoA. Together with FLAm, IQGAP1 inhibits Rac1 activity (b). The role of IQGAP1 on Rac/Rho is regulated by HECTD1 (c). Removal of IQGAP1 from Focal complexs triggers the maturation of focal adhesions by recruiting more paxillin and zyxin (d). HECTD1 is a key regulator of IQGAP1 and through this interaction HEDTD1 impacts on cellular adhesion and movement