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Fig. 7 | Cell Communication and Signaling

Fig. 7

From: Epigenetic regulation of transcription factor promoter regions by low-dose genistein through mitogen-activated protein kinase and mitogen-and-stress activated kinase 1 nongenomic signaling

Fig. 7

Schematic illustration of MAPK/MSK1/Histone H3 pathway on target gene transcription. The MAPK/MSK1/Histone3 pathway induced by genistein via nongenomic transient interactions of ERα with receptor tyrosine kinases (IGF-IR) and activation of MAPKp44/42/ERK1/2 [9], with recruitment and phosphorylation of MSK1 and activation of Histone H3 leading to enrichment of promoter regions of transcription factors EGR1, Elk1, ID-1 and cMyb and the genes transcription in human uterine leiomyoma (ht-UtLM) cells

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Cell Communication and Signaling

ISSN: 1478-811X