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Fig. 3 | Cell Communication and Signaling

Fig. 3

From: A new mode of SAM domain mediated oligomerization observed in the CASKIN2 neuronal scaffolding protein

Fig. 3

A comparison of the CASKIN1 (PDB: 3SEI) and CASKIN2 SAM domain tandem oligomers. Each SAM1-SAM2 tandem is colored individually, with SAM1 represented by a darker shade. The repeating unit is boxed. All of the intra- and intermolecular SAM domain interactions shown follow a head-to-tail type interaction. The head surface is derived from helices 2, 3 and 4 while the tail surface is predominantly derived from helix 5. To the right of each structure is a schematic illustrating the interactions between head and tail surfaces. An asterisk denotes available head and tail surfaces. Note that the CASKIN1 oligomer can only grow as a fibril in both directions while the CASKIN2 oligomer can form a branched structure

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Cell Communication and Signaling

ISSN: 1478-811X