Table 6 Overview of parameters used for the integrative model

Initial number of phagophores

3

Initial size of phagophores

0.07 μm²

Creation rate of phagophores

0.44 min^-1

Linear nutrient factor creation phagophores

0.206

Exponential nutrient factor creation phagophores

1.179

Mean maturation time of phagophores

7.5 min

Growth rate of phagophores

5e-04 μm² min^-1

Initial number of autophagosomes

31

Growth rate of autophagosomes

8e-05 μm² min^-1

Initial number of lysosomes

19

Initial size of lysosomes

0.1 μm²

Creation rate of lysosomes

1.23 min^-1

Linear nutrient factor creation lysosomes

0.112

Exponential nutrient factor creation lysosomes

1.124

Mean life time of lysosomes

18 min

Growth rate of lysosomes

0.0021 μm² min^-1

Initial number of autolysosomes

28

Initial size of autolysosomes

0.225 μm²

Degradation rate autolysosomes

0.15 min^-1

Linear nutrient factor degradation autolysosomes

0.0069

Exponential nutrient factor degradation autolysosomes

3.14

Growth rate of autolysosomes

0.00065 μm² min^-1

Chance of reformation autolysosome to lysosome

50%

Rate of movement

2 μm min^-1

Chance of autophagosomal movement towards nucleus

85%

Chance of lysosomal movement towards nucleus basis

55%

Chance of lysosomal movement towards nucleus via nutrient status

+0.5% DifferenceNutrition^-1

Chance of fusion of a non-autolysosome and an autolysosome

45%

Chance of fusion of two autolysosomes

30%

Mean free nutrients for initialization of the model

20

Mean bound nutrients for initialization of the model

20

Diffusion of free nutrients

70%

Diffusion of bound nutrients

50%

Local increase of free nutrients

1.1 min^-1 borderpatch^-1

Global decrease of free nutrients

0.05 min^-1 patch^-1

Global conversion of free nutrients to bound nutrients

0.045 min^-1 patch^-1

Lysosomal conversion of bound nutrients to free nutrients

1.5 min^-1 lysosome^-1

Autophagosomal uptake of bound nutrients

2.25 min^-1 autophagosome^-1

Autolysosomal release of free nutrients

2.25 min^-1 autolysosome^-1

Effect BAF on the degradation rate of autolysosomes

Degradation rate AL × 0.05