Volume 7 Supplement 1

12th Joint Meeting of the Signal Transduction Society (STS). Signal Transduction: Receptors, Mediators and Genes

Open Access

Endocytosis, cell signalling, adhesion and motility

  • HT McMahon1
Cell Communication and Signaling20097(Suppl 1):A101

DOI: 10.1186/1478-811X-7-S1-A101

Published: 26 February 2009

Endocytosis and exocytosis play a key role in how cells respond to their environment. Endocytosis directly (and indirectly) affects responses to guidance cues and growth factors, the uptake of nutrients and even pathogens; it modulates cell signalling in response to receptor activation and is essential for cell migration. In this talk I will consider the endocytic repertoire of a cell and show how distinct mechanisms may differently affect function. I will describe the characterisation of new endocytic mechanisms and show how a molecular understanding can lead to a better view of function. I will round up with a simple view of how exocytosis can be regulated by calcium mediated signalling.

Authors’ Affiliations

(1)
Neurobiology Division, MRC Laboratory of Molecular Biology

References

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Copyright

© McMahon; licensee BioMed Central Ltd. 2009

This article is published under license to BioMed Central Ltd.

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