Figure 2From: Eps15: a multifunctional adaptor protein regulating intracellular traffickingDifferent mechanisms for Eps15 ubiquitination. The E3 ligases Nedd4 and parkin ubiquitinate Eps15 by different mechanisms: Nedd4 needs to be ubiquitinated before binding to the Eps15-UIM can occur. Parkin contains a UBL domain which binds constitutively to the UIMs of Eps15. HECT and RING domains are indicated in their respective E3 ligases.Back to article page