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Figure 2 | Cell Communication and Signaling

Figure 2

From: Nuclear trafficking of secreted factors and cell-surface receptors: new pathways to regulate cell proliferation and differentiation, and involvement in cancers

Figure 2

Summary of the diverse pathways of nuclear shuttling and nuclear functions of secreted proteins and cell surface receptors. Trf: transferrin; Imp: importin; Exp: exportin; RNA PolII: RNA polymeraseII; (Ub)n: polyubiquitination; Splic: splicing machinery; UBS: upstream factor binding site; FT: transcription factor (For nuclear EGFR, the E2F1 and STAT3 transcription factors were identified as binding partners).

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Cell Communication and Signaling

ISSN: 1478-811X