From: Orphan nuclear receptor NR2F6 acts as an essential gatekeeper of Th17 CD4+ T cell effector functions
NR2F1 | NR2F2 | NR2F6 | |
---|---|---|---|
Immune system | T cell development, activation thresholds, CD4+Th17 autoimmunity, leukemia[51, 53, 54, 57, 64, 98] | ||
T cells[27], http://www.immgen.org | + | + | +++ |
B cells[27], http://www.immgen.org | + | + | +++ |
Development | Embryo, eye, hair, ear, angiogenesis [99] | ES cell differentiation, mesenchyme, angiogenesis, vessel identity, cerebellum, lymphangiogenesis, stomach, eye, osteoblast [34, 100–102] | |
Hormone regulation | LHβ, Vegf, LH, receptor, RAR [103] | ||
Cancer | Breast & prostate cancer, MC-lymphoma, metastasis, AML [43, 105] | ||
Metabolism | Insulin secretion, adipogenesis, energy metabolism | ||
CNS | Axons formation | [109] | |
Cortex patterning | |||
Fate specification | |||
Kidney | Renin production | ||
Reproduction | Reproduction |