Table 1 miR-125b associated with oncogenic signaling in cancer
From: Good guy or bad guy: the opposing roles of microRNA 125b in cancer
Tumor type | Direction of misregulation | miR-125b targets | Comments | Ref. |
|---|---|---|---|---|
Hematopoetic tumors | Up | BCL2 | Regulator of apoptosis | [26] |
|  | Up | CBFβ | Counteracts myeloid cell differentiation | [27] |
| Â | Up | Trp53inp1 | Regulator of apoptosis | [43] |
| Â | Up | NA | NA | [25] |
Colon cancer | Up in colon cancer with poor prognosis | p53 | Prognostic indicator for colorectal cancer | [38] |
Non-small-cell lung cancer (NSCLC) | Up in serum from patients with poor prognosis | NA | Prognostic serum marker for NSCLC | [44] |
Follicular cancer | Up | NA | NA | [29] |
Gastric tumors | Up | NA | Pro-proliferative, anti-apoptotic | [28] |
Pancreatic cancer | Up | NA | NA | [30] |