Figure 4From: C3G forms complexes with Bcr-Abl and p38α MAPK at the focal adhesions in chronic myeloid leukemia cells: implication in the regulation of leukemic cell adhesionC3G, Cbl, Abi1, p130Cas and p38α MAPK regulate adhesion to fibronectin in K562 cells. (A) Percentage of adhesion to fibronectin of K562 cells upon knock-down of C3G (shC3G-1 and shC3G-8), Cbl (shCbl-1), Abi1 (Abi1-2) or p130Cas (shp130Cas-5). (B) Percentage of adhesion to fibronectin of K562 clones expressing interference RNAs (cloned in pSuper.gfp/neo) for C3G and/or p38α MAPK. The values are the mean ± SEM of at least three independent experiments. All values are relative to K562 cells transfected with control shRNA or empty pSuper.gfp/neo vector (pSuper). *p<0.05; ** p<0,01.Back to article page