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Figure 6 | Cell Communication and Signaling

Figure 6

From: Direct transdifferentiation of spermatogonial stem cells to morphological, phenotypic and functional hepatocyte-like cells via the ERK1/2 and Smad2/3 signaling pathways and the inactivation of cyclin A, cyclin B and cyclin E

Figure 6

Albumin synthesis, urea productions, and cellular uptake and release of ICG of mature hepatocyte-like cells derived from SSCs. (A) ELISA showed albumin synthesis of SSCs (lane 1), mature hepatocyte-like cells derived from SSCs (lane 2), and primary hepatocytes (lane 3). “*” indicated statistically significant differences (p< 0.05) between SSCs and mature hepatocyte-like cells derived from SSCs or primary hepatocytes. (B) Urea assay displayed urea production of SSCs (lane 1), mature hepatocyte-like cells derived from SSCs (lane 2), and primary hepatocytes (lane 3). “*” indicated statistically significant differences (p< 0.05) between SSCs and mature hepatocyte-like cells derived from SSCs or primary hepatocytes. (C-G) Cellular uptake (C) and release (D) of ICG in mature hepatocyte-like cells derived from SSCs, uptake of ICG in SSCs (E), as well as uptake (F) and release (G) of ICG in mouse primary hepatocytes. Scale bars in C-G = 50 μm.

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Cell Communication and Signaling

ISSN: 1478-811X