Figure 5

Gene expression pattern and interaction in networks involved in macrophage activation (A and B), fMLP-stimulation (C and D) or PMN recruitment and activation (E and F) in the lungs of Mtb-infected rabbits at 3 hours. (A) Interaction of macrophage activation network genes in the HN878-infected rabbit lungs. (B) Intensity plot of macrophage activation network genes in the Mb-infected rabbit lungs. (C) Interaction among genes involved in fMLP-stimulated network in the HN878-infected rabbit lungs. (D) Intensity plot of genes involved in fMLP-stimulated network in Mtb-infected rabbit lungs. (E) Interaction of PMN recruitment and activation network genes in the HN878-infected rabbit lungs. (F) Intensity plot of PMN recruitment and activation network genes in the Mb-infected rabbit lungs. The legend for the gene symbols in (A), (C) and (E) is the same as in Figure 4. Gene symbols in red are up and green are down regulated. The color gradient of the gene symbols is proportional to their relative expression levels. Solid lines indicate direct and broken lines denote indirect interactions. For (B), (D) and (F), the gene expression values were sorted in a descending fashion for the HN878 dataset. The color scale in (B), (D) and (F) ranges from +3 (red) to −3 (blue).