Figure 4

Interaction and expression pattern of canonical STAT1 mechanistic pathway genes and STAT1 interaction network genes in Mtb-infected rabbit lungs. (A) STAT1 regulation of downstream transcriptional regulators. Solid arrows indicate direct and broken arrow indicates indirect interactions. Predictions on the direction and intensity of activation and inhibition by STAT1 were made by IPA knowledgebase based on published literature. (B) Intensity plot of 260 SDEG involved in canonical STAT1 mechanistic pathway in HN878- or CDC1551-infected rabbit lungs at 3 hours. The color scale ranges from +3 (red; upregulation) to −3 (blue; downregulation). (C and D) Interaction of STAT1 network genes in HN878- (C) or CDC1551- (D) infected rabbit lungs at 3 hours. Solid lines indicate direct interactions and broken lines denote indirect interactions of genes. For (C) and (D), gene symbols in red are up and green are down regulated. The color gradient of the gene symbols is proportional to their relative expression levels.