Figure 2

Genome-wide rabbit lung transcriptome and profile of significantly differentially expressed genes (SDEG) at 3 hours post-Mtb-infection. (A). Principal component analysis (PCA) of microarray gene expression datasets from uninfected, Mtb HN878- or CDC1551-infected rabbit lungs at 3 hours. The elliptical line around each data point represents the standard deviation from the median. (B). Intensity plot of SDEG in rabbit lungs following HN878 or CDC1551 infection at 3 hours. Gene expression values were sorted in a descending fashion for the HN878 dataset. The color scale ranges from +3 (red; upregulation) to −3 (blue; downregulation) (C). Venn diagram showing the number of genes obtained from pair wise comparison between uninfected and Mtb HN878- or CDC1551-infected animals.