Figure 6From: Platelet-derived growth factor-induced Akt phosphorylation requires mTOR/Rictor and phospholipase C-γ1, whereas S6 phosphorylation depends on mTOR/Raptor and phospholipase DSchematic representation of PDGF-BB-mediated regulation of Akt and S6. Initially, PDGF-BB-mediated activation of Akt involves both mTORC2 and the PLCγ/PKC pathways. Activation of S6 downstream of mTORC1 depends on PLD activation, independent of mTORC2 and Akt signaling. Ca2+ is required for regulation of Akt and S6 activity.Back to article page