From: Atypical IκB proteins – nuclear modulators of NF-κB signaling
BCL-3 | IκBζ | IκBNS | IκBη | IκBL | |
---|---|---|---|---|---|
Alternative names | B-cell CLL/lymphoma 3 , D19S37, AI528691 | Nfkbiz, FLJ30225, FLJ34463, INAP, MAIL, AA408868 | Nfkbid, IkB-delta, MGC11314, MGC149503, TA-NFKBH, T-cell activation NFKB-like protein | Ankrd42, FLJ37874, SARP, 4931426M20, 4933417L02Rik | LST1, NF-kappa-B inhibitor-like protein 1 |
Chromosomal Localisation (NCBI geneID) | Human: | Human: | Human: | Human: | Human: |
19q13.1-q13.2 | 3p12-q12 | 19q13.12 | 11q14.1 | 6p21.3 | |
(602) | (64332) | (84807) | (338699) | (4795) | |
Mouse: | Mouse: | Mouse: | Mouse: | Mouse: | |
7A3; 7 9.95 cM | 16; 16 C1.2-C1.3 | 7 B1; 7 | 7; 7E2 | 17 B1; 17 | |
(12051) | (80859) | (243910) | (73845) | 18.6 cM (18038) | |
Interaction partners | p50[35, 36, 40], p52[32], c-Jun[41], c-Fos[41], CREB/p300[41, 43], SRC-1[41], B3BP[42], Tip60[43], HDAC-1/-3/-6[37, 45] | p50[64], STAT3[71], FUSS-DDIT3[72], p65[73], RORγ[77], RORα[77] | p50[87] | Unknown | |
Tissue specific protein expression | Bone marrow, spleen, lymph nodes, peritoneal lavage, kidney, liver[52] | Heart, skeletal muscle, spleen, kidney, liver, placenta, lung, peripheral blood, leukocytes[73] | Spleen[78] | Brain, lung, kidney, testis, ovary[87] | Human PMBCs[88] |
Knockout phenotype | Reduction of Peyer’s Patches[53]. Lack of splenic marginal centers[51]. | Dermatitis-like skin irritations[74]. Ocular surface inflammation[76]. Resistant to EAE[77]. | Less Treg cells[80]. | Unknown | Unknown |
Induced via | LPS[61], IL-1[64], BLP[64], PGN[64], MALP[64], Flagellin[64], peptidoglycan[67], β-glucan[67], CpG-DNA[67], IL-18[70], IL-12[70] | LPS[88] | |||
Direct target genes (ChIP, pulldown, EMSA) | IP-10[44], IL-10[44], MCP-1[44], CD95[44], CD40[44], IL-23p19[44], CyclinD1[32], TNFα[39], Gata3[55] | Unknown | Unknown |